Description

α-Cgrp (33-37) (Rat) is a synthetic peptide fragment corresponding to amino acid residues 33-37 of the rat Calcitonin Gene-Related Peptide (CGRP). This high-purity biochemical is a critical research tool for studying the structure, function, and receptor interactions of CGRP, a potent neuropeptide involved in vasodilation and pain signaling. It is essential for researchers and developers in neuroscience, cardiovascular research, and pharmaceutical discovery programs targeting migraine and inflammatory pathways.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating the physiological and pathological roles of CGRP.
• Receptor Binding Assays: Employed in competitive binding studies to characterize CGRP receptor subtypes (e.g., CGRP1, CGRP2) and screen for antagonists.
• Antibody Production & Validation: Serves as an immunogen for generating specific anti-CGRP antibodies or as a coating antigen in immunoassay development (ELISA).
• Signal Transduction Studies: Applied in cellular models to elucidate downstream signaling pathways (e.g., cAMP activation) triggered by CGRP receptor engagement.
• Pharmaceutical R&D: A key intermediate and analytical standard in the discovery and development of novel therapeutics for migraine, cardiovascular diseases, and inflammation.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on neurobiology, vascular biology, and peptide chemistry.

Basic Information

Product Name	α-Cgrp (33-37) (Rat)
CAS No.	132917-50-1
Molecular Formula	C24H41N7O7
Molecular Weight	539.63 g/mol
Synonyms	Calcitonin Gene-Related Peptide (33-37), Rat; α-CGRP (33-37); CGRP33-37 (Rat); H-Val-Tyr-Val-Asp-His-OH; CGRP Fragment (33-37); Calcitonin Gene-Related Peptide Fragment 33-37; rCGRP (33-37)
EINECS	Contact for details

Quality Control

Every batch of α-Cgrp (33-37) (Rat) is manufactured and tested under strict quality management systems. We guarantee high purity and batch-to-batch consistency through comprehensive analytical protocols, including HPLC for purity and MS for identity confirmation. A detailed Certificate of Analysis (COA) providing full specifications is supplied with each shipment to ensure compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. For long-term storage, consider lyophilized powder under inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.