Description

Neuropeptide Y (32-36) Amide, Cys- is a synthetic pentapeptide fragment derived from the C-terminal region of Neuropeptide Y (NPY), a key neuromodulator involved in numerous physiological processes. This specific amide-conjugated, cysteine-containing analog is a critical research tool for investigating NPY receptor subtype interactions and signaling pathways. It is primarily utilized by pharmaceutical researchers and neuroscientists in drug discovery programs targeting metabolic disorders, anxiety, cardiovascular function, and appetite regulation.

Application

• Neuroscience Research: Used as a receptor ligand and probe to study the structure-activity relationships (SAR) of NPY and its fragments at Y1, Y2, Y4, and Y5 receptor subtypes.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the design and screening of novel NPY receptor agonists and antagonists for therapeutic applications.
• Biochemical Assays: Employed in competitive binding assays, functional cellular assays, and signal transduction studies to elucidate the role of NPY in various biological systems.
• Metabolic Disorder Studies: Applied in research models to understand NPY's role in energy homeostasis, food intake, and obesity, aiding in the development of anti-obesity drugs.
• Cardiovascular Research: Investigated for its effects on vascular tone, blood pressure, and heart function due to NPY's known cardiovascular activities.
• Peptide Chemistry & Conjugation: The cysteine residue allows for specific chemical modifications, such as fluorescent labeling or carrier protein conjugation, to create specialized research tools.

Basic Information

Product Name	Neuropeptide Y (32-36) Amide, Cys-
CAS No.	132880-12-7
Molecular Formula	C27H44N10O7S
Molecular Weight	652.8 g/mol
Synonyms	NPY (32-36) amide, Cys-; Cys-NPY(32-36)-NH2; Neuropeptide Y Fragment 32-36 Amide (Cys-); L-Cysteinyl-L-tyrosyl-L-arginyl-L-leucyl-L-argininamide; CYSRYLR-NH2; [Cys32]-Neuropeptide Y (32-36) amide; NPY (Cys32, 32-36) amide
EINECS	Contact for details

Quality Control

Our Neuropeptide Y (32-36) Amide, Cys- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis to meet specific purity or packaging requirements is available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	± 10% of theoretical
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.