Description

6-Nitro-1H-Indole-3-Sulfonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its core value lies in its role as a versatile sulfonylation reagent, enabling the precise construction of complex molecules in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), specialty agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-containing drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require the indole sulfonyl chloride moiety for bioactivity.
• Chemical Biology & Proteomics: Serves as a reactive handle for labeling proteins or synthesizing activity-based probes (ABPs) due to its sulfonyl chloride group's affinity for nucleophiles.
• Material Science Research: Employed in the creation of functional polymers and organic electronic materials where the nitro-indole unit contributes to electron-accepting properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	6-Nitro-1H-Indole-3-Sulfonyl Chloride
CAS No.	132745-00-7
Molecular Formula	C8H5ClN2O4S
Molecular Weight	260.65 g/mol
Synonyms	6-Nitro-1H-indole-3-sulfonyl chloride; 1H-Indole-3-sulfonyl chloride, 6-nitro-; 6-Nitroindole-3-sulfonyl chloride; 3-Sulfonylchloride-6-nitroindole; 6-Nitro-1H-indol-3-ylsulfonyl chloride; 132745-00-7; 6-Nitroindol-3-sulfonsäurechlorid
EINECS	Contact for details

Quality Control

Our 6-Nitro-1H-Indole-3-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.