Description

Big Endothelin-2 (1-37) (Human) is a synthetic peptide fragment corresponding to the full-length human endothelin-2 hormone. This high-purity reference standard is critical for cardiovascular and cancer research, enabling precise study of endothelin receptor binding and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on developing novel therapeutics for hypertension, pulmonary arterial hypertension, and tumor biology.

Application

• Biomedical Research: Used as a key reference standard in studies investigating the ETB receptor selectivity and vasoconstrictive effects of endothelin peptides.
• Drug Discovery & Development: Serves as a critical tool for screening and validating potential endothelin receptor antagonists in cardiovascular and oncology pipelines.
• Assay Development & Calibration: Essential for the development and standardization of ELISA, RIA, and other immunoassays targeting endothelin-2.
• Academic & Clinical Studies: Supports fundamental research into the role of endothelin-2 in vascular biology, cell proliferation, and disease mechanisms.
• Quality Control: Employed as a system suitability standard in analytical laboratories to ensure the performance of chromatographic methods for peptide analysis.

Basic Information

Product Name	Big Endothelin-2 (1-37) (Human)
CAS No.	132699-72-0
Molecular Formula	C185H282N52O55S4
Molecular Weight	4251.8 g/mol
Synonyms	Endothelin-2 (1-37), human; ET-2 (1-37); Big ET-2; Preproendothelin-2 (93-129), human; Endothelin-2 Precursor (93-129); [Cys1, Cys3, Cys11, Cys15]-Endothelin-2 (Human); CAS 132699-72-0
EINECS	Contact for details

Quality Control

Our Big Endothelin-2 (1-37) (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.