Description

Fmoc-L-Homophenylalanine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This high-purity building block is critical for researchers and manufacturers creating complex peptides with enhanced stability and specific biological activity. It is primarily utilized in pharmaceutical R&D, biotechnology, and the production of therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the sequential assembly of peptide chains on resin.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation & Labeling: Used to incorporate the homophenylalanine moiety into proteins or other biomolecules for structural modification or study.
• Peptidomimetic Research: Enables the development of non-natural peptide analogs with improved metabolic stability and receptor affinity.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse compound libraries for high-throughput screening in drug discovery.
• Academic & Industrial R&D: Fundamental reagent for research in medicinal chemistry, biochemistry, and molecular biology.

Basic Information

Item	Details
Product Name	Fmoc-L-Homophenylalanine
CAS No.	132684-59-4
Molecular Formula	C25H23NO4
Molecular Weight	401.46 g/mol
Synonyms	Fmoc-Hph-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-homophenylalanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-phenylbutanoic acid; Fmoc-L-2-amino-4-phenylbutyric acid; Nα-Fmoc-L-homophenylalanine; Fmoc-L-β-homophenylalanine; N-Fmoc-L-homophenylalanine; L-Homophenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-L-Homophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.