Description

Fmoc-Glu(Obzl)-Oh CAS NO 132639-61-2 is a protected amino acid derivative, specifically an Fmoc-protected glutamic acid with its side-chain carboxyl group benzylated. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated synthesis of peptides containing glutamic acid residues.
• Pharmaceutical Research: Used in the development and production of peptide-based drugs, hormones, and vaccines.
• Combinatorial Chemistry: Serves as a building block for creating diverse peptide libraries for drug discovery and screening.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic & Industrial R&D: Employed in biochemical research to study protein-protein interactions, enzyme substrates, and receptor ligands.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Fmoc-Glu(Obzl)-Oh
CAS No.	132639-61-2
Molecular Formula	C₂₈H₂₇NO₆
Molecular Weight	473.52 g/mol
Synonyms	Fmoc-Glu(OBzl)-OH; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 5-benzyl ester; Fmoc-L-glutamic acid 5-benzyl ester; Fmoc-Glu(OBn)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]pentanedioic acid 5-benzyl ester; N-α-Fmoc-L-glutamic acid γ-benzyl ester; Fmoc-Glu-OBzl; Fmoc-Glu(Bzl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Obzl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and optical rotation analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in DMF)
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.