Description

Boc-L-Pro(4-N3)-Oh*Dcha (2S,4R) CAS NO 132622-68-5 is a high-purity, non-natural amino acid derivative featuring an azide functional group at the 4-position of the proline ring, protected with a tert-butyloxycarbonyl (Boc) group and isolated as a dicyclohexylamine (Dcha) salt. This compound is a critical building block in modern peptide synthesis and bioconjugation, enabling the site-specific introduction of bioorthogonal handles via click chemistry. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating peptide-drug conjugates, diagnostic probes, and advanced biomaterials where precise chemical modification is required.

Application

• Peptide Synthesis Building Block: Used in Solid-Phase Peptide Synthesis (SPPS) for incorporating azide-functionalized proline residues.
• Bioconjugation & Click Chemistry: The azide group enables efficient, selective conjugation with alkynes (via CuAAC or SPAAC) to label peptides with fluorophores, drugs, or other payloads.
• Pharmaceutical Intermediate: Serves as a key intermediate in the research and development of novel therapeutic peptides and peptide mimetics.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and protein-protein interactions.
• Material Science: Incorporation into polymers or surfaces to create functionalized biomaterials with specific biological activity.
• Antibody-Drug Conjugate (ADC) Linker Development: Explored in the design of novel, stable linkers for targeted cancer therapies.

Basic Information

Product Name	Boc-L-Pro(4-N3)-Oh*Dcha (2S,4R)
CAS No.	132622-68-5
Molecular Formula	C22H39N5O4
Molecular Weight	437.58 g/mol
Synonyms	(2S,4R)-1-[(tert-Butoxy)carbonyl]-4-azidopyrrolidine-2-carboxylic acid dicyclohexylamine salt; Boc-4-azido-L-proline DCHA salt; Boc-L-4-azidoproline dicyclohexylammonium salt; N-α-Boc-4-azido-L-proline DCHA salt; tert-Butyl (2S,4R)-4-azido-2-(carboxy)pyrrolidine-1-carboxylate dicyclohexylamine salt; 1-Boc-4-azido-L-proline DCHA salt; Azido-Pro(Boc)-OH•DCHA
EINECS	Contact for details

Quality Control

Our Boc-L-Pro(4-N3)-Oh*Dcha (2S,4R) is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is moisture-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]²⁰D	-40.0° to -50.0° (c=1 in Methanol)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.