Description

Exchanger Inhibitory Peptide is a synthetic peptide specifically designed to inhibit sodium-hydrogen exchanger (NHE) activity. This targeted action makes it a crucial research tool for studying ion transport mechanisms, cellular pH regulation, and related physiological and pathological processes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular, neurological, and metabolic disorder research.

Application

• Biomedical Research: Fundamental studies on sodium-hydrogen exchanger (NHE) isoforms and their role in cellular function.
• Cardiovascular Research: Investigation of NHE involvement in cardiac ischemia-reperfusion injury, hypertrophy, and heart failure.
• Neurological Research: Exploration of NHE function in neuronal injury, stroke models, and neuroprotection strategies.
• Metabolic Disorder Studies: Research into the role of ion exchangers in diabetes, obesity, and related metabolic pathways.
• Cell Culture & In Vitro Assays: Used as a specific inhibitor in cell-based experiments to modulate intracellular pH and sodium levels.
• Drug Discovery & Development: Serves as a reference compound and pharmacological tool for validating new NHE-targeting therapeutic candidates.

Basic Information

Product Name	Exchanger Inhibitory Peptide
CAS No.	132523-75-2
Molecular Formula	C44H71N13O12S
Molecular Weight	982.2 g/mol
Synonyms	NHE Inhibitory Peptide; Sodium-Hydrogen Exchanger Inhibitor; EIPA Amide; 5-(N-Ethyl-N-isopropyl)amiloride; Cariporide; HOE 642 (related compound); Benzoyl-Gly-Arg-Arg-Leu-Ser-Ile-Leu-Asp; Bz-Gly-Arg-Arg-Leu-Ser-Ile-Leu-Asp
EINECS	Contact for details

Quality Control

Our Exchanger Inhibitory Peptide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.