Description

Fmoc-Asn(Trt)-Opfp CAS NO 132388-64-8 is a protected amino acid derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). Its value lies in the orthogonal protection strategy, where the Fmoc group provides base-labile N-terminal protection, the Trt (trityl) group protects the asparagine side chain, and the Opfp (pentafluorophenyl) ester offers an efficient, activated carboxyl group for coupling. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the production of complex peptides, including therapeutic agents and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the Fmoc/t-Bu strategy, enabling the controlled, sequential assembly of peptide chains on resin.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery and diagnostics.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Industrial Research: A standard reagent in laboratories for studying protein structure-function relationships, signal transduction, and molecular recognition.
• Synthesis of Difficult Sequences: Particularly valuable for incorporating asparagine residues while minimizing side reactions like aspartimide formation, thanks to the Trt side-chain protection.

Basic Information

Product Name	Fmoc-Asn(Trt)-Opfp
CAS No.	132388-64-8
Molecular Formula	C46H34F5N3O6
Molecular Weight	819.78 g/mol
Synonyms	Fmoc-L-asparagine(Trt)-OPfp ester; N-α-Fmoc-N-β-trityl-L-asparagine pentafluorophenyl ester; Fmoc-Asn(Trt)-OPfp; Fmoc-Asn(Trt)-O-Pfp; N-(9-Fluorenylmethoxycarbonyl)-N'-trityl-L-asparagine pentafluorophenyl ester; Fmoc-Asparagine(trityl)-OPfp; Fmoc-N-β-trityl-L-asparagine pentafluorophenyl ester; Fmoc-Asn(Trt)-OPfp CAS 132388-64-8
EINECS	Contact for details

Quality Control

Our Fmoc-Asn(Trt)-Opfp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and chiral purity essential for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and traceability, supporting compliance in GMP-oriented research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term storage under inert atmosphere, contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.