Description

Z-Gln(Trt)-Oh is a protected glutamine derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing a stable, orthogonal protecting group strategy for the glutamine side chain, preventing unwanted side reactions like dehydration to form nitriles during peptide chain assembly. This high-purity amino acid derivative is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled incorporation of glutamine residues into peptide sequences.
• Pharmaceutical Intermediate: Serves as a key raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial R&D for constructing model peptides, epitope mapping, and structure-activity relationship (SAR) studies.
• Bioconjugation: Can be utilized in the synthesis of peptide tags and linkers for protein labeling and bioconjugation applications.
• Combinatorial Chemistry: Employed in libraries for drug discovery to introduce glutamine motifs.
• Production of Complex Peptides: Critical for synthesizing long-chain or difficult-sequence peptides where side-chain protection is paramount.

Basic Information

Product Name	Z-Gln(Trt)-Oh
CAS No.	132388-60-4
Molecular Formula	C32H30N2O5
Molecular Weight	522.59 g/mol
Synonyms	Nα-Carbobenzyloxy-Nγ-trityl-L-glutamine; Nα-Cbz-Nγ-trityl-L-glutamine; Z-L-Glutamine Nγ-trityl; Cbz-Gln(Trt)-OH; (2S)-5-Oxo-2-[[(phenylmethoxy)carbonyl]amino]-5-[(tritylamino)amino]pentanoic acid; Z-Glutamine(Trt)-OH; N-Cbz-N'-trityl-L-glutamine; Fmoc-Gln(Trt)-OH precursor
EINECS	Contact for details

Quality Control

Our Z-Gln(Trt)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.