Description

Fmoc-Asn(Trt)-Oh CAS NO 132388-59-1 is a protected amino acid derivative, specifically N-α-Fmoc-N-β-trityl-L-asparagine, which serves as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing orthogonal protection for the side chain amide group of asparagine, preventing unwanted side reactions and enabling the efficient, high-fidelity assembly of complex peptides. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who are developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the controlled, sequential addition of asparagine residues using Fmoc-chemistry protocols.
• Pharmaceutical R&D: For the research and development of novel peptide-based drugs, including hormones, antibiotics, and targeted therapies.
• Combinatorial Chemistry: Used in libraries for drug discovery to create diverse arrays of peptide sequences for screening.
• Bioconjugation: Acts as a precursor for introducing asparagine sites into proteins or other biomolecules for labeling or functionalization.
• Academic Research: Fundamental studies in biochemistry, enzymology, and molecular biology involving peptide structure and function.
• Custom Peptide Service Providers: A standard reagent for companies offering bespoke peptide synthesis services to clients worldwide.

Basic Information

Product Name	Fmoc-Asn(Trt)-Oh
CAS No.	132388-59-1
Molecular Formula	C38H32N2O5
Molecular Weight	596.67 g/mol
Synonyms	N-α-Fmoc-N-β-trityl-L-asparagine; Fmoc-L-asparagine(trityl)-OH; Fmoc-Asn(Trt)-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(tritylamino)-3-oxopropanoic acid; N-(9-Fluorenylmethoxycarbonyl)-N'-trityl-L-asparagine; Fmoc-Asn(Mtr)-OH (common alternate abbreviation); Fmoc-Asparagine(Trt)-OH; N-Fmoc-N'-trityl-L-asparagine
EINECS	Contact for details

Quality Control

Our Fmoc-Asn(Trt)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive SPPS applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: -15.0° to -20.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.