Description

Z-Asn(Trt)-OH is a protected asparagine derivative widely used as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides with precise sequence control. It is primarily utilized in pharmaceutical R&D, biotechnology, and the production of therapeutic peptides and APIs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical intermediate for the controlled incorporation of asparagine into peptide chains.
• Pharmaceutical Research: Used in the development and scale-up of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Bioconjugation: Serves as a modified amino acid for creating peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships.
• Biochemical Research: A reagent for studying enzyme-substrate interactions and protein folding mechanisms.
• Custom Peptide Service: A fundamental raw material for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Z-Asn(Trt)-OH
CAS No.	132388-57-9
Molecular Formula	C31H28N2O5
Molecular Weight	508.57 g/mol
Synonyms	Nα-Carbobenzyloxy-Nβ-trityl-L-asparagine; Z-L-Asparagine N-trityl; Z-Asparagine(Trt)-OH; Nα-Cbz-Nβ-Trt-L-asparagine; Z-Asn(Trt); Cbz-Asn(Trt)-OH; N-Carbobenzyloxy-N'-tritylasparagine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-[(tritylamino)carbonyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Z-Asn(Trt)-OH is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -14.0° (c=1 in DMF)
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.