Description

H-Ala-Pro-Leu-Oh is a high-purity tripeptide derivative, specifically the C-terminal carboxylic acid form of the sequence Alanine-Proline-Leucine. This compound is a critical building block in advanced peptide synthesis and pharmaceutical research, offering precise structural control for developing novel therapeutic agents and biochemical tools. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in peptide-based drug discovery and development.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the solid-phase and solution-phase synthesis of longer, biologically active peptide chains for drug candidates.
• Biochemical Research: Used as a standard or reference compound in proteomics research, enzyme-substrate studies, and metabolic pathway analysis.
• Peptide Library Construction: An essential component for generating combinatorial peptide libraries used in high-throughput screening for drug discovery.
• Cosmetic Peptide Synthesis: Employed in the development of specialized bioactive peptides for advanced skincare and cosmetic formulations.
• Academic Research: Utilized in university and institutional labs for studying peptide structure-activity relationships (SAR) and molecular biology.

Basic Information

Product Name	H-Ala-Pro-Leu-Oh
CAS No.	132365-81-2
Molecular Formula	C14H25N3O4
Molecular Weight	299.37 g/mol
Synonyms	Ala-Pro-Leu; Alanine-Proline-Leucine; APL; H-Ala-Pro-Leu-OH; L-Alanyl-L-prolyl-L-leucine; Tripeptide APL; (S)-2-((S)-1-((S)-2-Aminopropanamyl)pyrrolidine-2-carboxamido)-4-methylpentanoic acid; L-Leucine, L-alanyl-L-prolyl-
EINECS	Contact for details

Quality Control

Our H-Ala-Pro-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by mass spectrometry (MS) and infrared spectroscopy (IR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.