Description

2(1H)-Pyrimidinone, 4-Amino-1-[(2S)-2-Hydroxy-3-(Triphenylmethoxy)Propyl]- is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of advanced antiviral APIs, offering a defined stereochemical center essential for biological activity. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of Efavirenz and related non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment.
• Antiviral Drug Development: Serves as a crucial precursor in R&D for novel antiviral compounds targeting retroviruses.
• Process Chemistry & Scale-Up: Used in process optimization and commercial-scale GMP manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in mechanistic studies and as a reference standard in virology and enzymology research.
• Custom Synthesis: A starting material for the preparation of structurally analogous compounds for biological screening.

Basic Information

Item	Details
Product Name	2(1H)-Pyrimidinone, 4-Amino-1-[(2S)-2-Hydroxy-3-(Triphenylmethoxy)Propyl]-
CAS No.	132336-30-2
Molecular Formula	C24H23N3O3
Molecular Weight	401.46 g/mol
Synonyms	4-Amino-1-[(2S)-2-hydroxy-3-(trityloxy)propyl]-2(1H)-pyrimidinone; (2S)-4-Amino-1-[2-hydroxy-3-(triphenylmethoxy)propyl]-1,2-dihydropyrimidin-2-one; Efavirenz Intermediate; L-743,726 Intermediate; (-)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one related intermediate; 4-Amino-1-[(2S)-2-hydroxy-3-(triphenylmethoxy)propyl]pyrimidin-2(1H)-one
EINECS	Contact for details

Quality Control

This pharmaceutical intermediate is produced under strict quality management systems. Every batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for API synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.