Description

Nalpha-Fmoc-Ndelta-Trityl-L-Glutamine is a high-purity, orthogonally protected derivative of the amino acid L-glutamine, specifically engineered for solid-phase peptide synthesis (SPPS). This compound matters as a critical building block, offering selective deprotection strategies essential for constructing complex peptides and peptide mimetics with high fidelity. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected glutamine residue in Fmoc/tBu-based synthesis strategies, where the trityl (Trt) group protects the side-chain amide.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation and Labeling: Acts as a precursor for introducing glutamine residues with a selectively addressable side-chain for subsequent chemical modification.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Synthesis of Peptide Fragments: Essential for the segment condensation approach to synthesize long or challenging peptide sequences.
• Biochemical Research: Used in studies of protein-protein interactions, enzyme substrates, and receptor ligands where specific glutamine positioning is required.

Basic Information

Product Name	Nalpha-Fmoc-Ndelta-Trityl-L-Glutamine
CAS No.	132327-80-1
Molecular Formula	C39H34N2O5
Molecular Weight	610.70 g/mol
Synonyms	Fmoc-Gln(Trt)-OH; N-α-Fmoc-N-δ-trityl-L-glutamine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-oxo-5-(tritylamino)pentanoic acid; Fmoc-L-glutamine(trityl); Fmoc-Gln(Trt); Nα-Fmoc-Nδ-trityl-L-glutamine; L-Glutamine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N5-(triphenylmethyl)-
EINECS	Contact for details

Quality Control

Our Nalpha-Fmoc-Ndelta-Trityl-L-Glutamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.