Description

Duramycin B is a specialized lantibiotic peptide known for its potent biological activity and specific interaction with phosphatidylethanolamine in cell membranes. This compound is of significant interest for its role as a research tool in membrane biology and as a lead structure for developing novel antimicrobial agents. It serves critical functions for researchers and developers in the pharmaceutical, biotechnology, and life science sectors, particularly in studies of membrane dynamics, apoptosis, and novel antibiotic discovery.

Application

• Biomedical Research: Used as a high-purity biochemical tool to study phosphatidylethanolamine exposure on cell surfaces and its role in processes like apoptosis and blood coagulation.
• Antimicrobial Development: Serves as a reference standard and lead compound in the research and development of new lantibiotic-based antibiotics targeting drug-resistant bacteria.
• Cell Biology Studies: Employed to investigate membrane asymmetry, pore formation, and ion channel activity in various eukaryotic and prokaryotic cell models.
• Pharmaceutical Screening: Acts as a positive control or active agent in high-throughput screening assays for discovering new membrane-active therapeutics.
• Veterinary Medicine Research: Explored for potential applications in developing treatments for bacterial infections in animals.
• Diagnostic Reagent Formulation: Utilized in the development of research-grade diagnostic kits for detecting specific membrane lipid alterations.

Basic Information

Product Name	Duramycin B
CAS No.	132246-31-2
Molecular Formula	C84H122N20O24S5
Molecular Weight	2012.4 g/mol
Synonyms	Moli1901; Lacticin 3147 A2; Duramycin B, Streptomyces cinnamoneus; (3S,6R,9S,12S,15S,18S,21S,24S,27S,30S,33S,36S,39S)-36-[(2S)-2-Aminobutanamido]-39-[[(2S)-1-[[(2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S,38S)-35-[[(2S)-2-Aminobutanamido]methyl]-8,17,26,29,32-pentakis(2-aminoethyl)-23-(carboxymethyl)-5,14-diethyl-11-(1-hydroxyethyl)-2,20-dimethyl-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxo-38-[[(2S)-1-oxo-1-[(2-sulfanylethyl)amino]propan-2-yl]amino]-3-oxa-6,9,12,15,18,21,24,27,30,33,36-undecazaoctatriacontyl]amino]-1-oxobutan-2-yl]amino]-30-(carboxymethyl)-6,15,24-triethyl-3,12,21-trimethyl-1,4,7,10,13,16,19,22,25,28,31,34-dodecaoxo-2-oxa-5,8,11,14,17,20,23,26,29,32,35-undecazaheptatriacontane-33-carboxylic acid
EINECS	Contact for details

Quality Control

Our Duramycin B is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and mass spectrometry for identity confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Potency (Microbiological Assay)	Contact for details
Endotoxin (LAL)	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.