Description

3,4,5-Trifluorobenzaldehyde is a high-purity fluorinated aromatic aldehyde serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity of the aldehyde group combined with the electronic effects imparted by the trifluoro substitution pattern, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and liquid crystal material industries who require reliable, high-quality intermediates for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, particularly in kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens, improving the dielectric anisotropy and stability of display components.
• Organic Electronic Materials: Employed in the synthesis of fluorinated organic semiconductors and charge-transport materials for OLEDs and OFETs.
• Cross-Coupling Reactions: The aldehyde functionality allows for further derivatization via reactions like Suzuki-Miyaura or Sonogashira coupling to create complex biaryl structures.
• Ligand and Catalyst Development: Useful for constructing fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3,4,5-Trifluorobenzaldehyde
CAS No.	132123-54-7
Molecular Formula	C7H3F3O
Molecular Weight	160.09 g/mol
Synonyms	3,4,5-Trifluorobenzenecarboxaldehyde; Benzaldehyde, 3,4,5-trifluoro-; 3,4,5-Trifluorobenzencarbonal; 3,4,5-Trifluorophenylformaldehyde; 3,4,5-Trifluorobenzaldehyd; 3,4,5-Trifluorobenzene-1-carbaldehyde; 3,4,5-Trifluoro-1-formylbenzene; 3,4,5-Trifluoro-1-benzaldehyde
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorobenzaldehyde is produced under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.