Description

Peptide 78 is a synthetic, biologically active peptide compound widely utilized in preclinical research and pharmaceutical development. It serves as a critical molecular tool for studying cell signaling pathways, receptor modulation, and structure–activity relationships in neuropharmacology and immunomodulation. Researchers and contract development and manufacturing organizations (CDMOs) across academia, biotech, and global pharmaceutical companies rely on high-purity Peptide 78 CAS NO 132116-62-2 for assay development, target validation, and lead optimization programs.

Application

• Neuroscience research: Investigation of neuropeptide receptor binding and downstream cAMP/ERK pathway activation
• Drug discovery: Use as a reference standard in HPLC and LC-MS method development and validation
• Biomarker studies: Functional probe for evaluating peptide transporter activity (e.g., PEPT1/2) in intestinal and renal models
• Vaccine adjuvant research: Evaluation of immunostimulatory effects in dendritic cell maturation assays
• Cell-based assay development: Dose-response characterization in G-protein coupled receptor (GPCR) functional assays
• Stability and degradation profiling: Reference material for forced degradation studies under thermal, oxidative, and hydrolytic stress conditions
• Custom conjugation platform: Amine-terminated variant used for fluorescent dye or biotin labeling in detection applications
• Regulatory filing support: Analytical reference standard included in IND/IMPD dossiers for peptide-based therapeutics

Basic Information

Product Name	Peptide 78
CAS No.	132116-62-2
Molecular Formula	C₇₈H₁₁₅N₂₁O₁₉
Molecular Weight	1654.9 g/mol
Synonyms	Peptide-78; P78; [D-Ala²]-Peptide 78; Ac-D-Ala-Gly-Phe-Leu-Met-NH₂ (analog); Neuropeptide Y fragment analog; NPY Y₂-receptor selective agonist; CAS 132116-62-2; Peptide 78 hydrate; Peptide 78 trifluoroacetate salt
EINECS	Not listed (not required for peptides under current EINECS scope)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Peptide 78 is tested for identity, purity (>98.5% by HPLC), residual solvents (per ICH Q3C), water content (Karl Fischer), and endotoxin levels (<0.1 EU/mg). Certificates of Analysis (COA) are available upon request and include full chromatograms, spectral data (FTIR, MS), and traceability to primary reference standards. All manufacturing complies with ISO 9001 and adheres to cGMP principles for research-grade peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C for long-term stability (recommended for ≥24 months). For short-term use (≤4 weeks), store desiccated at 2–8°C. Due to its hygroscopic nature, minimize exposure to ambient humidity during handling—use only in a controlled environment with nitrogen purging when opening vials.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	[M+H]⁺ ion at m/z 1655.9 ± 0.3
Assay (HPLC)	≥98.5%
Related Substances	Single impurity ≤0.5%; Total impurities ≤1.5%
Water Content (KF)	≤5.0%
Residual Solvents (Acetonitrile)	≤0.5%
Endotoxins	<0.1 EU/mg
pH (5 mg/mL in water)	5.5–7.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.