Description

Cholecystokinin (25-33), Tyr(25)-Nle(28,31)- is a synthetic peptide fragment of the gastrointestinal hormone cholecystokinin (CCK). This analog is specifically engineered with norleucine substitutions to enhance its stability and biological activity profile, making it a critical tool for receptor binding studies and signal transduction research. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on neurogastroenterology and metabolic disorders.

Application

• Biomedical Research: A key reagent for studying CCK receptor subtypes (CCKA and CCKB) and their role in pancreatic secretion, satiety, and anxiety.
• Drug Discovery: Used as a reference standard and pharmacological tool in high-throughput screening assays to identify novel agonists or antagonists for therapeutic development.
• Neuroscience Studies: Investigation of CCK's function as a neurotransmitter/neuromodulator in the central and peripheral nervous systems.
• Gastrointestinal Physiology: Research into the hormonal control of gallbladder contraction, pancreatic enzyme secretion, and gut motility.
• Metabolic Research: Exploration of the peptide's role in appetite regulation and energy homeostasis.
• In Vitro Diagnostics (IVD): Potential use in the development of immunoassays and diagnostic kits for research purposes.

Basic Information

Product Name	Cholecystokinin (25-33), Tyr(25)-Nle(28,31)-
CAS No.	132032-04-3
Molecular Formula	C58H84N14O14S
Molecular Weight	1233.4 g/mol
Synonyms	CCK (25-33), Tyr-Nle-CCK (25-33); CCK-9; Sincalide fragment (25-33) analog; [Tyr25, Nle28,31]-CCK (25-33); Cholecystokinin nonapeptide analog; CCK-8 (sulfated) analog; H-Tyr-Met-Gly-Trp-Nle-Asp-Phe-Nle-NH2 (sulfated); CCK receptor ligand.
EINECS	Contact for details

Quality Control

Our Cholecystokinin (25-33), Tyr(25)-Nle(28,31)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all specification parameters to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.