Description

2-Amino-4-Methoxyl-7-(2,3-o-Isopropylidene-5-o-tert-Butyldimethylsilyl--D-Ribofuranosyl)Pyrrolo[2,3-D]Pyrimidine is a sophisticated nucleoside analog intermediate of significant importance in advanced pharmaceutical research and development. This compound is a key protected precursor in the synthesis of modified nucleosides, which are critical for developing novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleotide-based drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel nucleoside analogs with potential antiviral and anticancer activities.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor for creating nucleoside-based chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for nucleotide APIs under GMP conditions.
• Biochemical Tool Development: Utilized to create labeled or modified nucleotides for molecular biology studies and diagnostic assays.
• Academic & Institutional Research: Provides a specialized starting material for investigating structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	2-Amino-4-Methoxyl-7-(2,3-o-Isopropylidene-5-o-tert-Butyldimethylsilyl--D-Ribofuranosyl)Pyrrolo[2,3-D]Pyrimidine
CAS No.	131981-22-1
Molecular Formula	C23H36N4O5Si
Molecular Weight	476.65 g/mol
Synonyms	7-((2R,3R,4R,5R)-3,4-Dihydroxy-5-((((R)-1,2,3,4-tetrahydroisoquinolin-3-yl)carbamoyl)oxy)methyl)tetrahydrofuran-2-yl)-2-amino-4-methoxypyrrolo[2,3-d]pyrimidine (related protected form); 2-Amino-4-methoxy-7-(2,3-O-isopropylidene-5-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; Protected Tubercidin Analog; silyl-protected nucleoside intermediate; TBDMS-protected pyrrolopyrimidine nucleoside
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing key parameters such as assay (HPLC), chiral purity, and impurity profiles. We support development with custom synthesis and analytical method development to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.