Description

2-(Trifluoromethyl)Piperazine is a high-value, fluorinated heterocyclic building block essential for modern synthetic chemistry. Its core value lies in the unique combination of the piperazine scaffold with the metabolically stable and lipophilic trifluoromethyl group, enabling the fine-tuning of drug-like properties. This compound is critically needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, particularly in medicinal chemistry for creating candidates with enhanced bioavailability and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) drugs, antivirals, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves compound efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and electronic chemicals.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences industry.
• Bioconjugation & Probe Design: Useful in creating chemical probes and bioconjugation reagents for biochemical and diagnostic applications.

Basic Information

Product Name	2-(Trifluoromethyl)Piperazine
CAS No.	131922-05-9
Molecular Formula	C5H9F3N2
Molecular Weight	154.13 g/mol
Synonyms	2-(Trifluoromethyl)piperazine; 2-Trifluoromethylpiperazine; 1-Piperazine, 2-(trifluoromethyl)-; α-Trifluoromethylpiperazine; Piperazine, 2-(trifluoromethyl)-; TFMP; 2-CF3-Piperazine
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant regulatory frameworks for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.