Description

3-Fluoro-4-Nitrobenzyl Bromide is a versatile and high-value halogenated aromatic building block essential for advanced organic synthesis. Its molecular structure, featuring both a reactive benzyl bromide group and electron-withdrawing nitro and fluoro substituents, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated benzyl moiety.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and molecular recognition studies.
• Material Science Research: Acts as a building block for creating advanced polymers, liquid crystals, or organic electronic materials with tailored properties.
• Chemical Biology Probes: Utilized to synthesize fluorescent tags or affinity probes for studying biological systems.
• Cross-Coupling Reactions: A valuable substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.

Basic Information

Item	Details
Product Name	3-Fluoro-4-Nitrobenzyl Bromide
CAS No.	131858-37-2
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	1-(Bromomethyl)-3-fluoro-4-nitrobenzene; 4-Nitro-3-fluorobenzyl Bromide; α-Bromo-3-fluoro-4-nitrotoluene; (3-Fluoro-4-nitrophenyl)methyl Bromide; 3-Fluoro-4-nitrobenzylbromide; 3-Fluoro-4-nitro-α-bromotoluene; 3-Fluoro-4-nitrobenzyl bromide
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Nitrobenzyl Bromide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under an inert atmosphere such as nitrogen for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.