Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6,8-Difluoro-1,4-Dihydro-4-Oxo- is a high-purity advanced pharmaceutical intermediate (API intermediate) of significant commercial importance. This compound is a key synthetic precursor in the production of modern fluoroquinolone antibiotics, valued for its precise molecular structure which is critical for biological activity. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and active pharmaceutical ingredient (API) producers engaged in the synthesis of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Core building block for the synthesis of novel fluoroquinolone antibiotic APIs.
• Antibacterial Drug Research: Critical material in R&D for developing new antibacterial compounds with improved efficacy and spectrum.
• Process Chemistry & Scale-Up: Used in process optimization and pilot-scale production runs for new drug candidates.
• Reference Standard: Serves as a high-purity chemical reference standard for analytical method development and quality control.
• Contract Manufacturing: Supplied to CMOs for the production of proprietary antibiotic formulations under cGMP conditions.
• Academic Research: Utilized in university and institutional research studying quinolone chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-7-(4-Ethyl-1-Piperazinyl)-6,8-Difluoro-1,4-Dihydro-4-Oxo-
CAS No.	131776-00-6
Molecular Formula	C19H21F2N3O3
Molecular Weight	377.39 g/mol
Synonyms	1-Cyclopropyl-7-(4-ethylpiperazin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-ethyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid; Gatifloxacin Intermediate; AM-1155 Intermediate; (±)-1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(4-ethyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid intermediate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical synthesis. Quality is verified through comprehensive analytical testing including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and impurity profiles. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.