Description

Ethyl 2-(Trifluoromethyl)Thiazole-5-Carboxylate is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is prized for its ability to introduce the metabolically stable and lipophilic trifluoromethyl-thiazole moiety into target molecules, significantly altering their physicochemical and biological properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in drug discovery programs targeting metabolic diseases, inflammation, and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl-thiazole group enhances bioactivity and environmental stability.
• Material Science Research: Serves as a precursor for the development of specialty chemicals, liquid crystals, and functional materials requiring specific electronic or optical properties.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or labeling agent in the design of chemical probes and enzyme inhibitors for biological pathway studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis providers and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	Ethyl 2-(Trifluoromethyl)Thiazole-5-Carboxylate
CAS No.	131748-96-4
Molecular Formula	C7H6F3NO2S
Molecular Weight	225.19 g/mol
Synonyms	Ethyl 2-(trifluoromethyl)-1,3-thiazole-5-carboxylate; 5-Thiazolecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester; 2-Trifluoromethyl-thiazole-5-carboxylic acid ethyl ester; Ethyl 2-(trifluoromethyl)-5-thiazolecarboxylate; 2-(Trifluoromethyl)-1,3-thiazole-5-carboxylic acid ethyl ester; Ethyl α,α,α-trifluoro-2-thiazolecarboxylate (ambiguous, not preferred); 131748-96-4
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-(Trifluoromethyl)Thiazole-5-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against comprehensive specifications. A detailed Certificate of Analysis (COA) providing identity, purity (typically by HPLC), and impurity profile is supplied with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.