Description

(5-Trifluoromethyl-Pyridin-3-Yl)-Methanol is a high-value trifluoromethylated pyridine derivative, a crucial building block in modern synthetic chemistry. Its core value lies in the unique combination of the pyridine heterocycle and the trifluoromethyl group, which imparts enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a key intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3-pyridine moiety contributes to improved efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring fluorinated aromatic components.
• Chemical Biology & Proteomics: Utilized as a building block for designing molecular probes and activity-based protein profiling (ABPP) agents.

Basic Information

Product Name	(5-Trifluoromethyl-Pyridin-3-Yl)-Methanol
CAS No.	131747-59-6
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	3-(Hydroxymethyl)-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)pyridine-3-methanol; (5-Trifluoromethyl-3-pyridyl)methanol; 3-Pyridinemethanol, 5-(trifluoromethyl)-; 5-Trifluoromethyl-3-pyridinemethanol; 5-Trifluoromethylnicotinyl alcohol
EINECS	Contact for details

Quality Control

Our (5-Trifluoromethyl-Pyridin-3-Yl)-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.