Description

Simendan CAS NO 131741-08-7 is a high-purity pharmaceutical intermediate and research chemical of significant interest in medicinal chemistry. This compound matters for its role as a key building block in the synthesis of novel therapeutic agents, particularly in cardiovascular research. Pharmaceutical manufacturers, biotechnology firms, and advanced research institutions require it for developing and scaling up new drug candidates. Its consistent quality and reliable supply are critical for ensuring the integrity of downstream pharmaceutical processes.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for cardiovascular drugs.
• Medicinal Chemistry Research: Serves as a core scaffold or precursor for the design and development of new chemical entities with potential therapeutic activity.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for use in custom synthesis and scale-up projects.
• Biochemical Research: Utilized in biochemical assays and pharmacological studies to investigate mechanisms of action and structure-activity relationships (SAR).
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Simendan
CAS No.	131741-08-7
Molecular Formula	C20H26N4O2
Molecular Weight	354.45 g/mol
Synonyms	Simendan; (-)-Simendan; (R)-Simendan; Levosimendan Impurity; 2-[[4-[(1R)-1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazono]propanedinitrile; 4-[(4R)-4-Methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl]-N'-[(Z)-(1-cyano-1-methyl-2-oxo-2-ethoxy)ethylidene]benzenehydrazide
EINECS	Contact for details

Quality Control

Our Simendan is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity determination and identity confirmation by spectroscopic methods (IR, NMR), to ensure it meets exacting standards for pharmaceutical R&D and manufacturing. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all test results against agreed specifications. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.