Description

1-((2R,4R,5S)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is a high-purity nucleoside derivative, a key chiral building block in advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups make it an essential intermediate for the development of novel antiviral and anticancer therapeutics. This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of nucleoside analogs and prodrugs.

Application

• Pharmaceutical Intermediate: Critical starting material for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the R&D of prodrugs targeting viral polymerases, particularly for hepatitis and herpesvirus families.
• Oncology Research: Serves as a building block for developing chemotherapeutic agents that interfere with DNA synthesis in rapidly dividing cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Chemistry: Used in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) requiring high stereochemical purity.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	1-((2R,4R,5S)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione
CAS No.	131682-41-2
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	5-Methyl-2'-deoxyuridine; 5-Methyldeoxyuridine; Thymidine, 2'-deoxy-; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; 2'-Deoxythymidine; dT; 5-Methyl-2'-deoxyuridine (enantiomerically pure); (2R,4R,5S)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl 5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-ide
EINECS	Contact for details

Quality Control

Our 1-((2R,4R,5S)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-5-Methylpyrimidine-2,4(1H,3H)-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.