Description

Amyloid β-Protein (Human, 25-35) Trifluoroacetate is a synthetic peptide fragment corresponding to residues 25-35 of the human amyloid β-protein, supplied as a trifluoroacetate salt. This specific sequence is a critical bioactive core region of the full-length amyloid beta peptide, widely used in fundamental neuroscience and Alzheimer's disease research. It is an essential biochemical tool for researchers and pharmaceutical developers studying protein aggregation, neurotoxicity mechanisms, and screening potential therapeutic compounds. The product is targeted at biotechnology, pharmaceutical R&D, and academic institutions focused on neurodegenerative disease models and drug discovery.

Application

• Neuroscience Research: Primary tool for studying the aggregation kinetics, fibril formation, and neurotoxic properties of amyloid beta peptides in vitro and in cell culture models.
• Alzheimer's Disease Modeling: Used to induce amyloid-related pathology and cognitive deficits in animal models for preclinical therapeutic evaluation.
• Drug Discovery & Screening: Serves as a key target in high-throughput screening assays to identify and validate novel inhibitors of amyloid beta aggregation or toxicity.
• Biophysical Studies: Employed in structural biology research using techniques like NMR, CD spectroscopy, and electron microscopy to understand peptide conformation and assembly.
• Antibody & Diagnostic Development: Used as an antigen for the production and characterization of antibodies, or as a standard in diagnostic assay development for amyloid detection.
• Mechanistic Toxicology: Applied in studies investigating the cellular pathways of oxidative stress, mitochondrial dysfunction, and apoptosis induced by amyloid peptides.

Basic Information

Item	Detail
Product Name	Amyloid β-Protein (Human, 25-35) Trifluoroacetate
CAS No.	131602-53-4
Molecular Formula	C55H89N19O19 • xC2HF3O2
Molecular Weight	1320.44 g/mol (Free base)
Synonyms	Amyloid β-Protein (25-35); Aβ (25-35); Amyloid β-Peptide (25-35); β-Amyloid (25-35); Aβ25-35; Amyloid β (25-35) fragment; H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH (TFA salt); Amyloidogenic peptide (25-35)
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (Human, 25-35) Trifluoroacetate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Solubility	Soluble in water, DMSO, or acetonitrile/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.