Description

Boc-D-Dap(Fmoc)-Oh is a protected amino acid derivative of significant importance in peptide synthesis. This compound is a crucial building block for the solid-phase and solution-phase construction of complex peptides, offering orthogonal protection for the side chain and α-amino group. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries to develop novel therapeutic peptides and peptidomimetics.

Application

• Peptide Synthesis Building Block: A key intermediate in the stepwise assembly of custom peptide sequences, particularly those containing diaminopropionic acid (Dap) residues.
• Pharmaceutical Research & Development: Used in the discovery and development of peptide-based drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Solid-Phase Peptide Synthesis (SPPS): Specifically designed for use in Fmoc-based SPPS methodologies, where the Boc group protects the α-amine and the Fmoc group protects the side-chain amine.
• Solution-Phase Peptide Synthesis: Employed in classical solution-phase coupling strategies for constructing specific peptide fragments.
• Bioconjugation and Labeling: Serves as a precursor for introducing functionalized diaminopropionic acid linkers into biomolecules for conjugation with dyes, drugs, or other molecules.
• Chemical Biology Probes: Integral to the synthesis of specialized peptides used as probes to study protein-protein interactions and enzyme function.

Basic Information

Product Name	Boc-D-Dap(Fmoc)-Oh
CAS No.	131570-56-4
Molecular Formula	C₂₄H₂₈N₂O₆
Molecular Weight	440.49 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-N-β-(9-fluorenylmethoxycarbonyl)-D-2,3-diaminopropionic acid; Boc-D-Dap(Fmoc)-OH; (2R)-3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid; tert-Butyl N-[(1R)-1-[[(9H-fluoren-9-ylmethoxy)carbonylamino]methyl]-2-carboxyethyl]carbamate; Boc-D-2,3-diaminopropionic acid(Fmoc)-OH; Fmoc-D-Dap(Boc)-OH; D-Dap(Boc,Fmoc)
EINECS	Contact for details

Quality Control

Our Boc-D-Dap(Fmoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity. Certificates of Analysis (COA) detailing specific results for identity, purity, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.