Description

6-(Difluoromethyl)Tryptophan is a fluorinated derivative of the essential amino acid tryptophan, distinguished by the presence of a difluoromethyl group on the indole ring. This structural modification is of significant interest in medicinal chemistry and pharmaceutical research, as it can dramatically alter the compound's metabolic stability, lipophilicity, and binding affinity. It serves as a critical building block and intermediate for researchers and manufacturers developing novel bioactive compounds, including enzyme inhibitors and peptide-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in oncology and neurology.
• Peptide Modification: Used to incorporate fluorinated tryptophan analogs into peptides to study and enhance their stability, activity, and receptor selectivity.
• Biochemical Research: Serves as a tool compound in enzymology studies to investigate enzyme mechanisms and inhibition, leveraging the fluorine atom's unique properties.
• Proteomics & Labeling: Potential use in the synthesis of probes and tags for mass spectrometry-based protein analysis and imaging.
• Agrochemical Research: As a specialty intermediate in the development of advanced crop protection agents with improved efficacy and environmental profiles.

Basic Information

Product Name	6-(Difluoromethyl)Tryptophan
CAS No.	131490-35-2
Molecular Formula	C₁₂H₁₂F₂N₂O₂
Molecular Weight	254.23 g/mol
Synonyms	6-(Difluoromethyl)-L-tryptophan; (S)-2-Amino-3-(6-(difluoromethyl)-1H-indol-3-yl)propanoic acid; DMF-Trp; 6-Difluoromethyltryptophan; Tryptophan, 6-(difluoromethyl)-; 6-(Difluoromethyl)-1H-indole-3-alanine
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure the integrity of our advanced intermediates. Each batch of 6-(Difluoromethyl)Tryptophan is analyzed using advanced techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. Our production adheres to cGMP principles where applicable, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.