Description

Histidylprolyl-2-Naphthylamide is a specialized synthetic peptide derivative, primarily utilized as a chromogenic substrate for enzymatic assays. This compound matters for its critical role in the detection and quantification of specific protease activities, offering high sensitivity and selectivity in biochemical research. It is needed by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic research institutions focused on enzymology and proteolytic pathway analysis.

Application

• Enzymatic Substrate: A key chromogenic substrate for the detection and kinetic study of specific proteases, including dipeptidyl peptidase IV (DPP-IV) and related enzymes.
• Biochemical Research: Used in fundamental research to investigate enzyme mechanisms, inhibition profiles, and substrate specificity in proteolytic cascades.
• Diagnostic Development: Employed in the development of in vitro diagnostic assays and kits for clinical and research use, enabling precise measurement of enzyme activity.
• Pharmaceutical Screening: Utilized in high-throughput screening (HTS) platforms to identify and characterize potential therapeutic enzyme inhibitors for drug discovery programs.
• Quality Control: Applied in the quality control of biopharmaceuticals to monitor the presence and activity of specific process-related enzymes.

Basic Information

Product Name	Histidylprolyl-2-Naphthylamide
CAS No.	131483-41-5
Molecular Formula	C₂₀H₂₄N₆O₂
Molecular Weight	380.45 g/mol
Synonyms	H-Pro-2-Naphthylamide; L-Histidyl-L-proline 2-naphthylamide; Histidyl-Proline 2-NA; DPP-IV Substrate; Gly-Pro-2-Naphthylamide analog; Peptide substrate 131483-41-5; H-His-Pro-2NA; 2-Naphthylamide derivative of Histidylproline
EINECS	Contact for details

Quality Control

Our Histidylprolyl-2-Naphthylamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. This material is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.