Description

Fmoc-Asn(Ac3Acnh-β-Glc)-Oh CAS NO 131287-39-3 is a specialized, protected asparagine derivative featuring an N-acetylglucosamine (GlcNAc) moiety, designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for the precise and efficient construction of glycopeptides, enabling research into protein glycosylation and its biological functions. It is an essential building block for pharmaceutical researchers, medicinal chemists, and biochemists working in drug discovery, glycobiology, and the development of therapeutic peptides and biologics.

Application

• Glycopeptide Synthesis: A key protected amino acid for the automated or manual synthesis of complex glycopeptides and glycoproteins.
• Drug Discovery & Development: Used to create peptide-based drug candidates with improved stability, bioavailability, and target specificity.
• Glycobiology Research: Enables the study of O-GlcNAcylation and other glycosylation pathways critical in cell signaling, metabolism, and disease.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled glycopeptide probes for diagnostic assays and imaging.
• Antibody-Drug Conjugate (ADC) Research: Used in the development of novel linker-payload systems for targeted cancer therapies.
• Enzyme Substrate & Inhibitor Design: Facilitates the creation of substrates or inhibitors for glycosyltransferases and other carbohydrate-processing enzymes.

Basic Information

Item	Details
Product Name	Fmoc-Asn(Ac3Acnh-β-Glc)-Oh
CAS No.	131287-39-3
Molecular Formula	C₃₃H₃₉N₃O₁₂
Molecular Weight	669.68 g/mol
Synonyms	Fmoc-Asn(Ac3AcNH-β-D-Glc)-OH; N-α-Fmoc-N-β-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-asparagine; Fmoc-Asparagine(Acetylglucosamine triacetate)-OH; Fmoc-Asn(GlcNAc(Ac)₃)-OH; Fmoc-L-Asn(Ac₃-β-D-GlcNAc)-OH; Fmoc-Asn(Ac₃-β-GlcNAc)-OH; Nα-9-Fluorenylmethoxycarbonyl-Nβ-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-L-asparagine
EINECS	Contact for details

Quality Control

Our Fmoc-Asn(Ac3Acnh-β-Glc)-Oh is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive research and development applications. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.