Description

Isopropyl 6-Methyl-4-(3-Nitrophenyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and neurological pathways. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel dihydropyrimidine (DHPM) and Biginelli reaction-derived drug candidates.
• API Synthesis: Used in the research and development of potential calcium channel blockers and other receptor-targeting molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and commercial production of proprietary pharmaceutical compounds.
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	Isopropyl 6-Methyl-4-(3-Nitrophenyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	131275-78-0
Molecular Formula	C16H17N3O5
Molecular Weight	331.32 g/mol
Synonyms	6-Methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid isopropyl ester; Isopropyl 4-(3-nitrophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 4-(3-Nitrophenyl)-6-methyl-3,4-dihydro-2(1H)-pyrimidinone-5-carboxylic acid 1-methylethyl ester; Biginelli Reaction Product; DHPM Derivative; 131275-78-0
EINECS	Contact for details

Quality Control

Our Isopropyl 6-Methyl-4-(3-Nitrophenyl)-2-Oxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production adheres to cGMP principles suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.