Description

(Tyr(Me)21)-Neuropeptide Y (Human, Rat) CAS NO 131256-74-1 is a chemically modified analog of Neuropeptide Y, a critical 36-amino acid peptide neurotransmitter involved in numerous physiological processes. This specific O-methylated derivative at tyrosine 21 is essential for advanced research into receptor binding affinity, signal transduction mechanisms, and metabolic regulation studies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, endocrinology, and metabolic disease drug discovery.

Application

• Neuroscience Research: Investigating the role of NPY in appetite regulation, anxiety, stress response, and circadian rhythms.
• Receptor Binding Studies: Used as a tool compound to study ligand-receptor interactions with NPY receptor subtypes (Y1, Y2, Y4, Y5, y6).
• Metabolic Disorder Research: Exploring pathways related to obesity, diabetes, and energy homeostasis.
• Cardiovascular Research: Studying NPY's effects on blood pressure, vasoconstriction, and angiogenesis.
• Biomarker Development: Aiding in the development of assays for detecting NPY pathway activity.
• Drug Discovery & Development: Serving as a reference standard or intermediate in the design of novel NPY receptor agonists or antagonists.

Basic Information

Product Name	(Tyr(Me)21)-Neuropeptide Y (Human, Rat)
CAS No.	131256-74-1
Molecular Formula	C192H290N56O57S
Molecular Weight	4253.7 g/mol
Synonyms	[Tyr(Me)21]-NPY; Neuropeptide Y (human, rat) [Tyr(Me)21]-; O-Methyl-L-tyrosine21-Neuropeptide Y; NPY (Tyr(Me)21); NPY, [Tyr(Me)21]-; Tyr(Me)21-NPY; NPY analog (Tyr(Me)21); NPY (22-36), [Tyr(Me)21]- (fragment notation may vary)
EINECS	Contact for details

Quality Control

Our (Tyr(Me)21)-Neuropeptide Y is manufactured under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to quality management principles aligned with GMP guidelines for active pharmaceutical ingredients (APIs) and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to reach room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by Mass Spectrometry
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.