Description

(R)-(-)-2-Amino-6-Phosphonohexanoic Acid Hydrate is a high-purity, chiral amino acid derivative that serves as a potent and selective antagonist for the metabotropic glutamate receptor subtype 6 (mGluR6). This compound matters for researchers and developers in neuroscience and pharmacology, as it is a critical tool for studying glutamatergic signaling pathways and developing novel therapeutic agents. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on neurological disorders, receptor characterization, and advanced chiral synthesis.

Application

• Neuroscience Research: A key pharmacological tool for selectively blocking mGluR6 receptors to study their function in retinal bipolar cells and visual signal processing.
• Drug Discovery & Development: Used as a reference standard and lead compound in the development of new therapeutics targeting neurological and ophthalmological conditions.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to evaluate compound activity and specificity against glutamate receptors.
• Academic & Clinical Studies: Facilitates fundamental research into glutamate's role in the central nervous system and potential links to diseases.
• Chiral Intermediate: Serves as a sophisticated building block in the asymmetric synthesis of more complex, biologically active molecules.
• Metabotropic Glutamate Receptor (mGluR) Specificity Profiling: Essential for mapping the selectivity profile of new compounds across the mGluR family.

Basic Information

Product Name	(R)-(-)-2-Amino-6-Phosphonohexanoic Acid Hydrate
CAS No.	131177-53-2
Molecular Formula	C₆H₁₄NO₆P • xH₂O
Molecular Weight	227.15 g/mol (Anhydrous basis)
Synonyms	(R)-AP6; (R)-2-Amino-6-phosphonohexanoic acid; (R)-2-Amino-6-phosphonocaproic acid; (R)-AP-6; (R)-2-Amino-6-phosphono-n-hexanoic acid; (R)-(-)-AP6 Hydrate; (R)-2-Amino-6-phosphonohexanoic acid hydrate; mGluR6 antagonist (R)-isomer
EINECS	Contact for details

Quality Control

Our (R)-(-)-2-Amino-6-Phosphonohexanoic Acid Hydrate is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤2.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.