Description

Cyclo(Phenylalanyl-4-Fluoro-Prolyl) CAS NO 131176-01-7 is a specialized cyclic dipeptide (diketopiperazine) derivative, engineered by incorporating a fluorine atom into the proline residue to enhance its biological stability and receptor binding affinity. This structural modification makes it a valuable intermediate and building block in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and research organizations focused on creating novel therapeutic agents, particularly in the areas of oncology, neurology, and metabolic diseases.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold for the synthesis of novel drug candidates, especially protease inhibitors and GPCR modulators.
• Peptidomimetics Research: Used in the design and development of peptidomimetic compounds to improve metabolic stability and oral bioavailability.
• Chemical Biology Probes: Acts as a key component in the creation of probes for studying enzyme mechanisms and protein-protein interactions.
• Combinatorial Chemistry: Employed in solid-phase and solution-phase peptide synthesis libraries for high-throughput screening.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for fundamental studies in peptide chemistry and medicinal chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and development programs.

Basic Information

Product Name	Cyclo(Phenylalanyl-4-Fluoro-Prolyl)
CAS No.	131176-01-7
Molecular Formula	C14H15FN2O2
Molecular Weight	262.28 g/mol
Synonyms	Cyclo(L-Phe-4-Fluoro-L-Pro); 4-Fluoro-Pro-Phe diketopiperazine; 3-Benzyl-6-(fluoromethyl)piperazine-2,5-dione; (3S,6S)-3-Benzyl-6-(fluoromethyl)piperazine-2,5-dione; Cyclo(Phe-4-F-Pro); 4-Fluoro-Prolyl-Phenylalanine DKP; FK-224 (related compound class); Cyclic dipeptide of 4-fluoro-proline and phenylalanine
EINECS	Contact for details

Quality Control

Our Cyclo(Phenylalanyl-4-Fluoro-Prolyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive spectroscopic identification (NMR, MS). A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.