Description

5-Oxo-L-Pro-1-[(2-Methylpropoxy)Carbonyl]-L-His-L-Pro-Nh2 is a synthetic tripeptide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a crucial building block and intermediate for the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing novel therapeutic agents, particularly in areas requiring specialized peptide modifications. The product is supplied under stringent quality controls to ensure consistency and reliability for critical R&D and cGMP manufacturing processes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel peptide-based drugs and therapeutic candidates.
• Peptide Chemistry Research: Used in academic and industrial laboratories for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.
• API Development: Serves as a critical intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical studies.
• Bioconjugation: Potential use in the development of peptide-drug conjugates (PDCs) and other targeted delivery systems due to its functional groups.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in peptide analysis.

Basic Information

Product Name	5-Oxo-L-Pro-1-[(2-Methylpropoxy)Carbonyl]-L-His-L-Pro-Nh2
CAS No.	130817-95-7
Molecular Formula	C20H30N6O6
Molecular Weight	450.49 g/mol
Synonyms	5-Oxo-L-prolyl-L-histidyl-L-prolinamide, 1-[(2-Methylpropoxy)carbonyl]-; L-Histidyl-L-prolinamide, 5-oxo-L-prolyl-, 1-[(2-methylpropoxy)carbonyl]-; Boc-His-Pro-NH2 derivative; Tripeptide Derivative CAS 130817-95-7; 5-Oxo-Pro-His-Pro-NH2 (Isobutyloxycarbonyl protected); (S)-1-((S)-2-((S)-5-Oxo-2-pyrrolidinecarboxamido)-3-(1H-imidazol-4-yl)propanamido)pyrrolidine-1-carboxylic acid isobutyl ester
EINECS	Contact for details

Quality Control

Our 5-Oxo-L-Pro-1-[(2-Methylpropoxy)Carbonyl]-L-His-L-Pro-Nh2 is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can support development with specifications aligned with ICH guidelines for impurities and stability, ensuring data integrity for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Total)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.