Description

Somatostatin, Azidonitrobenzoyl-Lys(4)-Iodo-Tyr(11)- is a chemically modified, photoactivatable analog of the endogenous peptide hormone somatostatin. This specialized compound is engineered for advanced biochemical research, particularly in receptor mapping and cross-linking studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotech companies focused on neuroendocrinology, oncology, and drug discovery.

Application

• Photoaffinity Labeling: Acts as a critical tool for irreversibly binding to and identifying somatostatin receptor subtypes (SSTRs) in complex biological systems.
• Receptor Structure-Function Studies: Used to investigate ligand-receptor interactions and the molecular architecture of binding sites.
• Bioconjugation and Probe Development: Serves as a precursor for creating fluorescent or radioactive probes for imaging and detection assays.
• Target Validation in Drug Discovery: Supports the identification and validation of SSTRs as therapeutic targets for conditions like acromegaly, neuroendocrine tumors, and diabetic retinopathy.
• Biochemical Mechanism Research: Enables studies on somatostatin's signaling pathways and its modulatory effects on hormone secretion.

Basic Information

Product Name	Somatostatin, Azidonitrobenzoyl-Lys(4)-Iodo-Tyr(11)-
CAS No.	130772-40-6
Molecular Formula	C76H106N20O19S2
Molecular Weight	1635.9 g/mol
Synonyms	4-Azido-2-nitrobenzoyl-Lys(4)-Iodo-Tyr(11)-Somatostatin-14; ANB-Lys(4)-Iodo-Tyr(11)-SRIF-14; Photoactivatable Somatostatin Analog; SSTR Photoaffinity Label; Azidonitrobenzoyl-modified Somatostatin; Iodo-Tyr(11)-Somatostatin Derivative; CAS 130772-40-6
EINECS	Contact for details

Quality Control

This high-purity research biochemical is manufactured under controlled conditions. Each batch undergoes rigorous analytical testing including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, solvent content, and performance data are available upon request to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Biological Activity	Assayed by receptor binding

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.