Description

Z-Gly-Arg-Thiobenzyl Ester CAS NO 130698-88-3 is a specialized, high-purity peptide derivative designed for advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and a potent, irreversible inhibitor for cysteine proteases, particularly cathepsins B and L, enabling precise study of enzymatic pathways. It is essential for researchers and manufacturers in the fields of protease inhibitor development, peptide synthesis, and drug discovery, where reliable quality and structural integrity are paramount.

Application

• Protease Inhibition Research: A key substrate and irreversible inhibitor for studying the kinetics and mechanisms of cysteine proteases like cathepsin B and L.
• Pharmaceutical Intermediate: Used in the synthesis of more complex peptide-based drug candidates targeting protease-related diseases.
• Biochemical Assay Development: Employed in the design and validation of high-throughput screening (HTS) assays for identifying novel protease inhibitors.
• Enzymology Studies: Facilitates research into enzyme specificity, active site mapping, and the role of proteases in physiological and pathological processes.
• Academic & Industrial R&D: A vital tool for universities, research institutes, and biotech companies engaged in fundamental life science research and therapeutic development.

Basic Information

Product Name	Z-Gly-Arg-Thiobenzyl Ester
CAS No.	130698-88-3
Molecular Formula	C24H30N6O5S
Molecular Weight	514.60 g/mol
Synonyms	Z-Gly-Arg-SBzl; Benzyloxycarbonyl-Gly-Arg-thiobenzyl ester; CBZ-Gly-Arg-SBzl; Z-Gly-Arg-S-Benzyl Ester; N-Carbobenzoxy-glycyl-arginine thiobenzyl ester; Cathepsin B Inhibitor (Z-Gly-Arg-SBzl); Protease Substrate Z-Gly-Arg-SBzl; Z-Gly-Arg-Thiobenzyl
EINECS	Contact for details

Quality Control

Every batch of Z-Gly-Arg-Thiobenzyl Ester is manufactured under strict quality management systems. We guarantee high purity and batch-to-batch consistency through comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformity to your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.