Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl Lys(Boc)-Pro-Oh is a protected dipeptide derivative, specifically Fmoc-Lys(Boc)-Pro-OH, which serves as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides orthogonal protection for the lysine side chain and proline residue, enabling the precise, sequential construction of complex peptides and proteins. Pharmaceutical researchers, biotech companies, and CROs specializing in peptide-based drug discovery and development are the primary users of this high-purity intermediate.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected building block for the automated synthesis of therapeutic peptides.
• Peptide Drug Discovery: Used in research and development of novel peptide-based pharmaceuticals targeting GPCRs, enzymes, and other biological pathways.
• Antibody-Drug Conjugate (ADC) Linker-Payload Construction: Incorporation into specialized peptide linkers that connect cytotoxic agents to monoclonal antibodies.
• Bioconjugation and Labeling: Serves as a chemical handle for attaching fluorophores, biotin, or other probes to peptides for diagnostic and research applications.
• Combinatorial Chemistry Libraries: A key component in generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Institutional Research: Used in biochemical and structural biology studies to investigate protein-protein interactions and enzyme mechanisms.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl Lys(Boc)-Pro-Oh
CAS No.	130445-10-2
Molecular Formula	C30H37N3O7
Molecular Weight	551.64 g/mol
Synonyms	Fmoc-Lys(Boc)-Pro-OH; N-α-Fmoc-N-ε-Boc-L-lysyl-L-proline; Fmoc-Lys(Boc)-L-Pro-OH; (9-Fluorenylmethoxycarbonyl)-N-ε-(tert-butoxycarbonyl)-L-lysyl-L-proline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-[(1,1-dimethylethoxy)carbonyl]-L-lysyl-L-proline; Fmoc-Lys(Boc)-Pro; Boc-Lys(Fmoc)-Pro-OH; Fmoc-Lys(Boc)-Pro
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl Lys(Boc)-Pro-Oh is manufactured under strict quality systems to ensure consistency and reliability for sensitive synthetic applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, specific rotation, and residual solvent levels is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	-40.0° to -44.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.