Description

α-Msh (4-10)Nh2, Ac-Nle(4)-Glu(γ-4'-Hydroxyanilide)(5)-Phe(7)- is a synthetic peptide fragment of α-Melanocyte-Stimulating Hormone (α-MSH), specifically the 4-10 sequence, modified with an acetylated norleucine at position 4 and a γ-4'-hydroxyanilide derivative of glutamic acid at position 5. This engineered analog is designed for enhanced stability and specific receptor binding affinity, making it a critical research tool for studying melanocortin receptor pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on dermatology, inflammation, and metabolic disorders.

Application

• Biomedical Research: As a reference standard and active agent in studies of melanocortin receptors (MC1R, MC3R, MC4R, MC5R).
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for novel therapeutics targeting pigmentation, appetite regulation, and anti-inflammatory responses.
• Mechanistic Studies: Investigating intracellular signaling pathways, including cAMP production and MAPK/ERK activation, mediated by α-MSH analogs.
• In Vitro & In Vivo Assays: Functional characterization of peptide activity in cell-based models and animal studies related to skin biology and energy homeostasis.
• Analytical Standard: Serves as a high-purity calibrant for method development and validation in HPLC, LC-MS, and other analytical techniques.
• Peptide Chemistry & Conjugation: A model compound for studying structure-activity relationships (SAR) and developing novel peptide-drug conjugates.

Basic Information

Product Name	α-Msh (4-10)Nh2, Ac-Nle(4)-Glu(γ-4'-Hydroxyanilide)(5)-Phe(7)-
CAS No.	130333-59-4
Molecular Formula	C52H68N12O13
Molecular Weight	1045.2 g/mol
Synonyms	Ac-Nle-Glu(4-Hydroxyanilide)-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2; α-MSH (4-10) amide, Ac-Nle4, Glu(4-HA)5; Melanotropin (4-10) fragment analog; Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 related peptide; N-Acetyl-Nle-Glu(4-hydroxyanilide)-Phe-Arg-Trp-Gly-Lys-Pro-Val-amide; MC1R ligand analog; Modified α-MSH 4-10 sequence; Research peptide 130333-59-4
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of α-Msh (4-10)Nh2, Ac-Nle(4)-Glu(γ-4'-Hydroxyanilide)(5)-Phe(7)- undergoes comprehensive testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We support research requiring compliance with GMP-grade materials for preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion [M+H]+ matches theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.