Description

Corticotropin-Releasing Hormone, Iodo-Tyr(0)- CAS NO 130120-58-0 is a chemically modified, iodinated analog of the neuropeptide corticotropin-releasing hormone (CRH). This specialized derivative is critical for advanced biochemical research and diagnostic development, offering enhanced properties for receptor binding studies and tracer applications. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on neuroendocrinology, stress response pathways, and peptide hormone analysis.

Application

• Biochemical Research: Used as a high-affinity radioligand or tracer in receptor binding assays and autoradiography studies for CRH receptors (CRHR1 and CRHR2).
• Neuroendocrine Studies: A key tool for investigating the hypothalamic-pituitary-adrenal (HPA) axis, stress physiology, and related disorders.
• Diagnostic Development: Serves as a critical component in the development of immunoassays and diagnostic kits for measuring CRH levels.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel CRH receptor antagonists or agonists for therapeutic development.
• Metabolic Pathway Analysis: Facilitates studies on the role of CRH in appetite regulation, anxiety, and inflammatory responses.
• Peptide Chemistry & Conjugation: Acts as a model iodinated peptide for developing novel conjugation techniques and studying peptide stability.

Basic Information

Item	Detail
Product Name	Corticotropin-Releasing Hormone, Iodo-Tyr(0)- CAS NO 130120-58-0
CAS No.	130120-58-0
Molecular Formula	C207H340N60O63S
Molecular Weight	~4750 g/mol (Contact for exact value)
Synonyms	Iodo-CRH; CRH, Iodo-Tyr(0)-; Iodinated Corticotropin-Releasing Hormone; Iodo-Tyr0-CRH; CRH (Iodo-Tyr); Corticoliberin, Iodo-Tyr(0)-; Sauvagine, Iodo-Tyr(0)- (related analog); Urocortin I, Iodo-Tyr(0)- (related analog)
EINECS	Contact for details

Quality Control

Our Corticotropin-Releasing Hormone, Iodo-Tyr(0)- is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and specific activity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Specific Activity	Contact for details
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.