Description

n-(4-Trifluoromethyl-Phenyl)-Guanidine is a specialized guanidine derivative featuring a trifluoromethylphenyl substituent, which imparts unique electronic and steric properties. This compound serves as a high-value pharmaceutical intermediate and a versatile building block in advanced organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel molecules with targeted biological or physical activities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Organic Synthesis Reagent: Used as a guanylation agent or a directing group in palladium-catalyzed cross-coupling reactions.
• Material Science Research: Intermediate for creating functionalized polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probes: Serves as a core structure for developing enzyme inhibitors or molecular probes for biological target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client-specific projects.

Basic Information

Product Name	n-(4-Trifluoromethyl-Phenyl)-Guanidine
CAS No.	130066-24-9
Molecular Formula	C8H8F3N3
Molecular Weight	203.17 g/mol
Synonyms	1-(4-(Trifluoromethyl)phenyl)guanidine; N-(4-Trifluoromethylphenyl)guanidine; 4-(Trifluoromethyl)phenylguanidine; Guanidine, N-[4-(trifluoromethyl)phenyl]-; (4-Trifluoromethylphenyl)guanidine; α,α,α-Trifluoro-p-tolylguanidine; p-(Trifluoromethyl)phenylguanidine
EINECS	Contact for details

Quality Control

Every batch of n-(4-Trifluoromethyl-Phenyl)-Guanidine is manufactured under a cGMP-compliant quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.