Description

H-D-Mephe-Ome Hcl is a protected amino acid derivative, specifically the hydrochloride salt of the methyl ester of H-D-Mephe. This compound serves as a crucial chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the production of peptides and other bioactive molecules. Its defined stereochemistry and high purity are essential for ensuring the efficacy and consistency of the final active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-configuration of methylphenylalanine into peptide chains.
• Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic candidates.
• Bioconjugation: Acts as a modified amino acid for creating custom peptides used in drug delivery systems and diagnostic probes.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	H-D-Mephe-Ome Hcl
CAS No.	130008-09-2
Molecular Formula	C11H15NO2 • HCl
Molecular Weight	229.70 g/mol (Free base: 193.24 g/mol)
Synonyms	H-D-Mephe-OMe • HCl; Methyl (2R)-2-amino-3-phenylpropanoate hydrochloride; D-Methylphenylalanine methyl ester hydrochloride; (R)-2-Amino-3-phenylpropionic acid methyl ester hydrochloride; Methyl D-α-phenylalanine ester hydrochloride; H-D-Phe(4-Me)-OMe • HCl (if referring to methyl derivative); Fmoc-D-Mephe-Ome Hcl (protected form); D-Mephe-OMe hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Mephe-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.