Description

3-Azidotyrosine is a specialized, non-canonical amino acid derivative where an azido functional group is introduced into the tyrosine side chain. This compound is a critical building block in chemical biology and pharmaceutical research, enabling site-specific protein modification through bioorthogonal click chemistry reactions. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and novel therapeutic development, where precise labeling and functionalization of biomolecules are required.

Application

• Bioconjugation & Protein Labeling: Used as a metabolic precursor for incorporating azide handles into proteins for subsequent click chemistry coupling with alkynes (e.g., for fluorescent probes, affinity tags).
• Chemical Biology Probes: Enables the study of protein function, localization, and interactions in live cells via bioorthogonal labeling strategies.
• Antibody-Drug Conjugate (ADC) Development: Serves as a linker component for creating stable, site-specific conjugates between monoclonal antibodies and cytotoxic payloads.
• Peptide & Protein Engineering: Incorporated into synthetic peptides or recombinant proteins to introduce novel chemical functionality for downstream applications.
• Materials Science: Functionalization of surfaces and polymers with bioactive peptides or proteins for biosensor and biomaterial development.
• Proteomics Research: Facilitates enrichment and identification of newly synthesized proteins in pulse-chase experiments and activity-based protein profiling.

Basic Information

Product Name	3-Azidotyrosine
CAS No.	129960-90-3
Molecular Formula	C9H9N5O3
Molecular Weight	235.20 g/mol
Synonyms	L-3-Azidotyrosine; 3-Azido-L-tyrosine; Azidotyrosine; (2S)-2-Amino-3-(4-azidophenyl)propanoic acid; 4-Azido-L-phenylalanine analogue; Tyr(N3); Click chemistry amino acid; Bioorthogonal amino acid; Non-canonical amino acid
EINECS	Contact for details

Quality Control

Our 3-Azidotyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Chiral Purity (HPLC)	≥98% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.