Description

Retroviral Nucleocapsid Protein Ncp10 is a highly specialized recombinant protein derived from the nucleocapsid (NC) domain of retroviral Gag polyproteins. This protein is critical for studying viral RNA genome packaging, virion assembly, and the structural dynamics of retroviral replication. It serves as an essential biochemical tool for researchers in virology, structural biology, and antiviral drug discovery, enabling detailed mechanistic studies and high-throughput screening assays.

Application

• Virology Research: Fundamental studies on retroviral life cycles, including HIV-1 and other lentiviruses.
• Drug Discovery & Screening: Target protein for identifying and validating novel antiviral compounds that inhibit nucleocapsid function.
• Structural Biology: Protein used in X-ray crystallography, NMR spectroscopy, and cryo-EM to elucidate the 3D structure of nucleocapsid-RNA complexes.
• Biochemical Assay Development: Key reagent for developing in vitro assays to study nucleic acid chaperone activity, zinc finger functionality, and protein-RNA interactions.
• Diagnostic Kit Component: Potential use as an antigen or capture protein in ELISA and other immunoassays for retroviral detection.

Basic Information

Product Name	Retroviral Nucleocapsid Protein Ncp10
CAS No.	129924-33-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ncp10 Protein; Retroviral Nucleocapsid Protein; HIV-1 NCp10; Nucleocapsid Protein p10; Gag NC Domain; Zinc Finger Protein NC; NC Protein; Retroviral Gag Nucleocapsid Domain
EINECS	Contact for details

Quality Control

Our Retroviral Nucleocapsid Protein Ncp10 is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes rigorous quality testing, including purity analysis, identity confirmation, and functional activity assays. Certificates of Analysis (COA) detailing specifications such as purity, concentration, endotoxin levels, and biological activity are provided to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Avoid repeated freeze-thaw cycles. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	≥ 95%
Identification (Mass Spec)	Conforms
Endotoxin Level	< 1.0 EU/μg
Biological Activity	Confirmed by nucleic acid binding assay
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.