Description

7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9-Fluoro-2,3-Dihydro-2-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-, (S)- (9Ci) is a high-purity advanced pharmaceutical intermediate with significant synthetic utility. This compound is valued for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is essential for pharmaceutical R&D and GMP manufacturing processes where precise molecular structure and high chemical purity are critical for efficacy and regulatory compliance.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A critical intermediate in the production of advanced fluoroquinolone antibiotics.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new antibacterial agents.
• Contract Manufacturing (CMO): Supplied to facilities specializing in the scale-up and commercial production of complex drug substances.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting and process optimization studies for more efficient API manufacturing.
• Academic Research: Used in university and institutional labs for studying structure-activity relationships (SAR) of antibacterial compounds.

Basic Information

Item	Details
Product Name	7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid, 9-Fluoro-2,3-Dihydro-2-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-, (S)- (9Ci)
CAS No.	129815-82-3
Molecular Formula	C19H21FN4O4
Molecular Weight	388.39 g/mol
Synonyms	(S)-9-Fluoro-2,3-dihydro-2-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; (S)-Ofloxacin Intermediate; Ofloxacin Impurity; Ofloxacin Related Compound; (S)-(-)-Ofloxacin Intermediate; 9-Fluoro-2,3-dihydro-2-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, (S)-; Levofloxacin Intermediate Precursor; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our 7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid intermediate is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical use. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.