Description

Phosphotyrosylangiotensin Ii is a chemically modified peptide analog of the vasoconstrictor hormone Angiotensin II, where a tyrosine residue has been phosphorylated. This specific modification is critical for research into signal transduction pathways, particularly those involving tyrosine kinase activity and receptor-mediated cardiovascular regulation. It is an essential biochemical tool for pharmaceutical R&D, academic research, and diagnostic development in the fields of hypertension, cardiovascular disease, and cellular signaling.

Application

• Biochemical Research: Used as a high-purity reference standard and substrate in studies of angiotensin receptor (AT1/AT2) signaling mechanisms and tyrosine phosphorylation events.
• Pharmaceutical Development: Serves as a key intermediate or active analog in the discovery and testing of novel antihypertensive drugs and cardiovascular therapeutics.
• Enzyme Assays: Acts as a specific substrate for studying the activity of protein tyrosine kinases (PTKs) and phosphatases (PTPs) involved in blood pressure regulation.
• Diagnostic Reagent Manufacturing: Employed in the production of calibration standards and components for immunoassays and other diagnostic kits targeting the renin-angiotensin system.
• Cell Signaling Studies: Utilized to investigate intracellular signaling cascades triggered by phosphorylated peptide hormones in vascular smooth muscle cells and other relevant tissues.
• Metabolic Pathway Analysis: Applied in research to trace the metabolic fate and degradation pathways of modified angiotensin peptides.

Basic Information

Product Name	Phosphotyrosylangiotensin Ii
CAS No.	129785-85-9
Molecular Formula	C50H68N13O12P
Molecular Weight	1050.12 g/mol
Synonyms	p-Tyr-Angiotensin II; Phospho-Tyr-Angiotensin II; [pTyr4]-Angiotensin II; Asp-Arg-Val-Tyr(PO3H2)-Ile-His-Pro-Phe; L-Aspartic acid, L-arginyl-L-valyl-O-phosphono-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; Phosphorylated Angiotensin II; Angiotensin II, 4-phosphotyrosine-
EINECS	Contact for details

Quality Control

Every batch of Phosphotyrosylangiotensin Ii is manufactured and analyzed under strict quality management systems to ensure the highest standards of purity and consistency for research use. Our quality control protocols include comprehensive analytical characterization using HPLC, MS, and NMR to verify identity, purity, and correct phosphorylation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO, acidic/basic aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.