Description

Big Endothelin 3 is a potent, 21-amino acid vasoconstrictor peptide belonging to the endothelin family. This compound is a critical research tool for studying cardiovascular physiology, receptor-ligand interactions, and signal transduction pathways. It is essential for researchers and developers in the fields of pharmaceutical R&D, biochemical research, and cardiovascular disease modeling, providing a high-purity standard for assay development and biological studies.

Application

• Biomedical Research: Used as a reference standard in studies investigating the ETB receptor subtype selectivity, vascular tone regulation, and cellular signaling mechanisms.
• Pharmaceutical Development: Serves as a key pharmacological tool for screening and characterizing potential endothelin receptor antagonists in drug discovery pipelines.
• In Vitro Diagnostics (IVD): Employed in the calibration and validation of immunoassay kits designed to detect and quantify endothelin peptides or related biomarkers.
• Cell Culture & Physiology Studies: Applied in experimental models to induce specific physiological responses, such as vasoconstriction, in isolated tissue or cell-based assays.
• Academic Research: Fundamental for university and institutional labs exploring the role of endothelins in health, disease states, and developmental biology.

Basic Information

Item	Detail
Product Name	Big Endothelin 3
CAS No.	129774-03-4
Molecular Formula	C121H168N26O37S4
Molecular Weight	2643.1 g/mol
Synonyms	Endothelin-3 (1-21), human, porcine; ET-3; Big ET-3; Big Endothelin-3; Endothelin 3 (1-21); Endothelin-3 Precursor (1-21); [Cys1,3,11,15, Ala7]-Endothelin-3 (human); hET-3 (1-21); Preproendothelin-3 (1-21)
EINECS	Contact for details

Quality Control

Our Big Endothelin 3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical results are available upon request to ensure traceability and meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.