Description

D-Magainin II Amide is a synthetic antimicrobial peptide (AMP) analog derived from natural magainin peptides found in frog skin. This compound is valued for its potent, broad-spectrum activity against bacteria, fungi, and other microorganisms while demonstrating relatively low cytotoxicity toward mammalian cells. It is a critical research tool and a promising candidate for the development of novel anti-infective agents, biomaterials, and preservative systems. Key industries that utilize this peptide include pharmaceutical R&D, biotechnology, and advanced materials science.

Application

• Antimicrobial Agent Research: Used as a reference standard and active component in studies exploring novel mechanisms of action against drug-resistant pathogens.
• Biomaterial Coating: Incorporated into surface coatings for medical devices (e.g., catheters, implants) to prevent biofilm formation and microbial colonization.
• Therapeutic Peptide Development: Serves as a lead compound or structural template for designing new peptide-based antibiotics and antifungal therapies.
• Cell Membrane Studies: Employed in biophysical research to investigate peptide-lipid bilayer interactions and membrane disruption mechanisms.
• Cosmetic & Personal Care Preservatives: Evaluated for use in formulations as a potential natural-origin preservative booster or alternative.
• Agricultural Biocontrol: Explored for applications in protecting crops from bacterial and fungal diseases.

Basic Information

Product Name	D-Magainin II Amide
CAS No.	129696-25-9
Molecular Formula	C135H228N44O33
Molecular Weight	2988.5 g/mol
Synonyms	D-Magainin 2 Amide; All-D-Magainin II Amide; Magainin II (D-isomer), amide; H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-NH2 (D-isomers); D-MAG; Antimicrobial Peptide D-Magainin-2 Amide; D-enantiomer of Magainin II amide
EINECS	Contact for details

Quality Control

Our D-Magainin II Amide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.